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  • Title: Stimulation of Na+ transport across the toad urinary bladder by p-chloromercuribenzene sulfonate.
    Author: Spooner PM, Edelman IS.
    Journal: Biochim Biophys Acta; 1976 Nov 11; 455(1):272-6. PubMed ID: 186128.
    Abstract:
    The sulfhydryl reagent p-chloromercuribenzene sulfonate increased the ISC across substrate-replete toad urinary bladder when applied to the mucosal (apical) surface. This increase was accounted for by an increased mucosal to serosal net flux of Na+. In the absence of substrate, the rise in ISC was accompanied by an irreversible increase in tissue conductance which was not apparent in the replete preparation. These findings suggest that p-chloromercuribenzene sulfonate may be useful in marking mucosal functions associated with the Na+ transport apparatus.
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