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  • Title: The SP-AP compound wave in patients with auditory neuropathy.
    Author: Lu Y, Zhang Q, Wen Y, Ji F, Chen A, Xi X, Li X.
    Journal: Acta Otolaryngol; 2008 Aug; 128(8):896-900. PubMed ID: 18612852.
    Abstract:
    CONCLUSIONS: This study suggests that the asynchronization of the cochlear afferent pathway may be one mechanism of the etiopathogenesis of auditory neuropathy. OBJECTIVE: To investigate the characteristics of the SP-AP compound wave and its generating mechanism in patients with auditory neuropathy. SUBJECTS AND METHODS: The electrocochleogram (ECochG) was recorded with external ear canal electrode in patients with auditory neuropathy and normal subjects. The peak-latency, amplitude, and time course of the SP-AP compound wave were measured by using an 'assessor-blind' study. The discrepancy between the two groups was evaluated by statistical analysis. RESULTS: The SP-AP compound waveform in the auditory neuropathy patient group was unrepresentative. The transient character of the SP-AP compound wave was more atypical than that for the normal cases. SP dominance (-SP/AP>0.4) appeared. The amplitude of both AP and SP was lower than that of the control group. The width of the SP-AP compound wave at one-third of its peak was greater than that of the control group.
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