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  • Title: Ribosome display selection of a metal-binding motif from an artificial peptide library.
    Author: Wada A, Sawata SY, Ito Y.
    Journal: Biotechnol Bioeng; 2008 Dec 01; 101(5):1102-7. PubMed ID: 18613123.
    Abstract:
    A new ribosome display system was applied for the in vitro selection of a metal-binding motif from an artificial peptide library. The display system consisted of an mRNA-associating protein, a ribosome, and mRNA. The protein part of this display system was designed to provide a random peptide library and to stabilize the ribosome display. The random peptide library was newly designed to isolate stable metal-binding motifs. We employed the system for in vitro selection and found several new proteins and peptides that bind Co(II)-immobilized resin and Co(II)-complex, respectively. This newly developed system can be conveniently applied to the in vitro selection of peptide aptamers.
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