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  • Title: Idiotype vaccine strategies for improving outcomes in follicular lymphoma.
    Author: Sinha R, Shenoy PJ, Flowers CR.
    Journal: Expert Opin Biol Ther; 2008 Aug; 8(8):1213-23. PubMed ID: 18613772.
    Abstract:
    BACKGROUND: Follicular lymphoma (FL) is a common indolent lymphoma associated with a relapsing course. Preclinical models and clinical studies demonstrate that immunizing FL patients against their own tumor idiotype induces humoral and cellular immunity and supresses tumor growth. METHODS: We review idiotype vaccine strategies that have been tested in FL patients in frontline and relapsed settings to examine the safety and efficacy of this approach. RESULTS: Several Phase II trials of recombinant or hybridoma-produced vaccines or vaccines combined with other immunotherapy demonstrate cellular and humoral anti-idiotype responses and clinical responses, indicating that idiotype vaccines provide promise for improving FL outcomes. CONCLUSION: These strategies are now being evaluated in Phase III trials but have yet to demonstrate clear advantages in progression-free survival.
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