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  • Title: Elevated circulating fetal nucleated red blood cells and placental pathology in term infants who develop cerebral palsy.
    Author: Redline RW.
    Journal: Hum Pathol; 2008 Sep; 39(9):1378-84. PubMed ID: 18614199.
    Abstract:
    An elevated circulating fetal nucleated red blood cell count has long been recognized as an indicator of significant intrauterine stress. However, the nature of the causative events and their timing remain controversial. In this study, subacute and chronic placental lesions known to be associated with neurodisability were used as surrogates for antenatal stress. Mother-infant pairs with complete blood counts within 2 hours of delivery (n = 81) were drawn from a larger database of 152 term infants with cerebral palsy. An elevated nucleated red blood cell count (2.5 x 10(3)/mm(3)) in these infants was associated with a significantly increased prevalence of subacute or chronic placental lesions, whereas clinical findings did not significantly differ. The number of nucleated red blood cells per 10 high-power fields of villous parenchyma was directly correlated with the nucleated red blood cell count, and a threshold of 10 or more nucleated red blood cells predicted a nucleated red blood cell count greater than 2.5 x 10(3)/mm(3). Among individual placental lesions, multiple foci of avascular villi and chronic villitis were significantly associated with an elevated nucleated red blood cell count, whereas meconium-associated vascular necrosis showed a borderline association. Acute chorioamnionitis was the only placental lesion more common in the group without elevated nucleated red blood cell count. The presence of significant placental lesions was associated with an elevated nucleated red blood cell count in infants with or without either acidosis (cord pH <7.0) or birth asphyxia (American College of Obstetrics and Gynecology criteria). Acidosis and birth asphyxia were not significantly related to an elevated nucleated red blood cell count in infants without these placental lesions.
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