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  • Title: Intracranial aneurysms in sickle cell patients: report of 2 cases and review of the literature.
    Author: Brandão RA, de Carvalho GT, Reis BL, Bahia E, de Souza AA.
    Journal: Surg Neurol; 2009 Sep; 72(3):296-9; discussion 299. PubMed ID: 18614211.
    Abstract:
    BACKGROUND: The sickle cell disease has different neurologic complications, including cerebral aneurysms. This disease may lead to endothelial damage, which favors the development of cerebral aneurysms. Only a few cases demonstrated by cerebral angiography or surgery have been reported in the English literature referring to cerebral aneurysms in sickle cell patients. CASE DESCRIPTION: We report 2 patients with sickle cell disease whose cerebral aneurysms were successfully treated by open surgery. CONCLUSION: Sickle cell patients have a high occurrence of multiple aneurysms, and a high prevalence of posterior circulation aneurysms. This must be interpreted with caution, and further studies are needed to confirm this association.
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