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  • Title: Successful kinase bypass with new acyclovir phosphoramidate prodrugs.
    Author: McGuigan C, Derudas M, Bugert JJ, Andrei G, Snoeck R, Balzarini J.
    Journal: Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4364-7. PubMed ID: 18614365.
    Abstract:
    Novel phosphoramidates of acyclovir have been prepared and evaluated in vitro against acyclovir-sensitive and -resistant herpes simplex virus (HSV) types 1 and 2 and varicella-zoster virus (VZV). Unlike the parent nucleoside these novel phosphate prodrugs retain antiviral potency versus the ACV-resistant virus strain, suggesting an efficient bypass of the viral thymidine kinase.
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