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  • Title: Synthesis and characterization of biologically significant 5,5'-(1,4-phenylene)bis(1-N-alkoxyphthalimido-3-aryl-2-pyrazoline) derivatives.
    Author: Lal Jat J, Ojha S, Bhambi D, Dhakar N, Talesara GL.
    Journal: J Enzyme Inhib Med Chem; 2008 Dec; 23(6):882-7. PubMed ID: 18618326.
    Abstract:
    A facile synthesis of 5,5'-(1,4-phenylene)bis(3-aryl-2-pyrazolines) 4a-g has been achieved by the cyclo-addition reaction of hydrazine hydrate with bis-substituted chalcones 3a-g, which in turn were prepared by the Clasien-Schmidt condensation of p-substituted acetophenones 1a-g with terephthaldehyde. Condensation of 4a-g with omega-bromoalkoxyphthalimides 5a-b afforded the titled compounds 6a-n, some of which exhibited significant antimalarial as well as antimicrobial activity.
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