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  • Title: [Study on antitumor activity of extract from roots of Gossampinus malabaria].
    Author: Qi YP, Zhu H, Guo SM, Jue HQ, Lin S.
    Journal: Zhong Yao Cai; 2008 Feb; 31(2):266-8. PubMed ID: 18619276.
    Abstract:
    OBJECTIVE: To study the antitumor activity of extract (Y2) from the roots of Gossampinus malabaria (L.) Merr. METHODS: Based on the inhibitory effects of Y2 on FGC-85 in vitro, life-prolonging effects of Y2 on mice transplanted with ascites sarcoma-180 (S-180) and antitumor activity of Y2 on mice transplanted with U14 were investigated in vivo. RESULTS: The growth of S-180 in mice was significantly inhibited by Y2. The inhibitory growth effect was dosage-dependent. Y2 could significantly prolong the survival time of mice transplanted with S-180. The inhibition rate of Y2 on the growth of U14 in mice was higher than 90% under high, medium and low dosage. CONCLUSION: Y2 has distinct antitumor activity.
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