These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effects of rat serum containing total flavonoid extract of Epimedium sagittatum on development of osteoblasts].
    Author: Ma HP, Jia ZP, Cheng KM, Zhang RX, Li MX, Wang J.
    Journal: Zhongguo Zhong Yao Za Zhi; 2008 Apr; 33(8):928-31. PubMed ID: 18619355.
    Abstract:
    OBJECTIVE: To investigate the effects of total flavonoid extract of Epimedium sagittatum (TFE) on the proliferation and differentiation of newborn rat calvarial osteoblasts (ROB). METHOD: TFE was supplemented into the culture medium of ROB at 0. 1, 1, 10 and 100 microg x mL(-1) respectively. The serum of rats administered TFES (SRAT) was also added into the medium in a parallel treatment at 2.5%, 5% and 10% respectively. Their effects on cell proliferation and differentiation was studied by MTT and the analysis of osteogenic differentiation marks. RESULT: TFE had no appreciable and on cell proliferation and differentiation at any concentration. However, 2.5% and 5% SRAT stimulated cell proliferation strongly and, 5% SRAT significantly promoted the maturation and function of osteoblast by improving the alkaline phosphatase activity, osteocalcin secretion, calcium deposition and the number of mineralized nodular structures. CONCLUSION: The metabolites of TFE should be the anti-osteoporosis constitutes of Epimedium sagittatum.
    [Abstract] [Full Text] [Related] [New Search]