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  • Title: Synthesis of some novel imidazole-based dicationic carbazolophanes as potential antibacterials.
    Author: Rajakumar P, Sekar K, Shanmugaiah V, Mathivanan N.
    Journal: Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4416-9. PubMed ID: 18620857.
    Abstract:
    Synthesis of fluorescent imidazole-based dicationic carbazolophanes incorporating various spacer units is described. Interestingly, the cyclophanes 2a and 5a incorporating a pyridine moiety exhibited superior antibacterial activity against most of the pathogenic bacteria in the tested concentrations as compared to the other cyclophanes as well as the test control, benzalkonium chloride (BAC), cetylpyridinium chloride (CPC) and tetracycline.
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