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  • Title: Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.
    Author: Adler M, Lazarus RA, Dennis MS, Wagner G.
    Journal: Science; 1991 Jul 26; 253(5018):445-8. PubMed ID: 1862345.
    Abstract:
    The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.
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