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  • Title: Mitotic delay and chromosomal aberrations induced by X rays in synchronized Chinese hamster cells in vitro.
    Author: Yu CK, Sinclair WK.
    Journal: J Natl Cancer Inst; 1967 Oct; 39(4):619-32. PubMed ID: 18623924.
    Abstract:
    Synchronized Chinese hamster cell populations in vitro were X-irradiated at different stages of the cell cycle and examined at the next metaphase. Mitotic delay varied according to the stage of the cell cycle at the time of irradiation. It was greatest for cells irradiated in middle to late S, moderate for cells irradiated in G2, and least for cells irradiated in G1. It increased approximately linearly with dose (0.7 hr./100 rad for S cells and 0.3 hr./100 rad for G1 cells). Chromosomal aberration rates also depended on the stage of the cell cycle at which the cells were irradiated. Chromatid aberrations were induced mostly during G2 and S (more in early S than late S), while chromosome aberrations were induced mainly in G1. Total breaks after 500 or 750 R showed a minimum frequency in late S and a maximum frequency in G2. This form of response correlates, but only in a general qualitative way, with the dependence of survival on cell cycle stage previously reported. Mitotic delay has a dependence on cell cycle stage quite different from either chromosomal aberrations or survival.
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