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  • Title: [Studies on the antitumor antibiotic aclacinomycin A].
    Author: Zhang H, Wang D, Xu S, Ye Y, Chen P.
    Journal: Wei Sheng Wu Xue Bao; 1991 Jun; 31(3):247-50. PubMed ID: 1862654.
    Abstract:
    During the course of screening for new antitumor antibiotics, a new anthracycline antibiotic--aclacinomycin A was separated from the broth and mycelium of Streptomyces AC-57. The strain AC-57 was isolated from the soil collected in the Shanghai suburbs. According to its culture and physiological characteristics the producer was identified as Str. galilaeus AC-57. The broth and mycelium were extracted and treated with solvents as usual way. The aclacinomycin A was separated by silica-gel column chromatography eluted with chrolo-form-methanol. Aclacinomycin A, its aglycone and sugar components were identified by comparison of their physico-chemical and spectral data (MS, UV, IR, 1H-NMR, and 13C-NMR) with authentic compound, purified from the market sample.
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