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  • Title: Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine.
    Author: Starke K, Borowski E, Endo T.
    Journal: Eur J Pharmacol; 1975 Dec; 34(2):385-8. PubMed ID: 186273.
    Abstract:
    Strips of the rabbit main pulmonary artery were preincubated with 3H-noradrenaline. 3 X 10(-8) -- 10(6) M yohimbine enhanced the overflow of tritium and the smooth muscle contraction induced by transmural sympathetic nerve stimulation. The increase of the stimulation-evoked overflow of tritium was prevented by a high concentration of oxymetazoline. The results indicate that yohimbine is more potent in blocking the presynaptic than the postsynaptic alpha-adrenoceptors of the artery.
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