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  • Title: Evidence of depressive symptoms in fragile-X syndrome premutated females.
    Author: Rodriguez-Revenga L, Madrigal I, Alegret M, Santos M, Milà M.
    Journal: Psychiatr Genet; 2008 Aug; 18(4):153-5. PubMed ID: 18628675.
    Abstract:
    OBJECTIVES: Fragile-X premutation carriers have been considered asymptomatic patients for a long time. It has been, however, demonstrated that the premutation is also involved in clinical pathology, such as premature ovarian failure, the fragile-X-associated tremor/ataxia syndrome, and a distinct neurocognitive and behavioral phenotype, which includes psychiatric problems. To define better this neuropsychiatric phenotype associated with premutation carriers and to minimize a possible environmental effect, we examined psychiatric and depressive symptoms in 34 FMR1 premutation carrier mothers of children with fragile-X syndrome in comparison with two control groups (39 mothers with a non-fragile-X syndrome mentally retarded child and 39 mothers from the general population). METHODS: All participants completed both questionnaires, which assess psychiatric symptoms (the symptom checklist-90-revised) and depression (Beck Depression Inventory). RESULTS: Both groups of mothers with a mentally retarded child showed greater susceptibility to psychological problems than the control group without a mentally retarded child, but FMR1 premutated mothers evidenced a higher tendency to depression. These results suggest that, despite the stress of caring for a child with mental retardation, the premutation by itself could be responsible for some psychiatric traits. CONCLUSION: Our findings reinforce the hypothesis of a pathogenic gene-brain-behavior mechanism in the premutation range.
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