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  • Title: [Acceleration of the restoration of conditioned reflexes following anesthesia using aminostigmine].
    Author: Prozorovskiĭ VB, Iudkina NI.
    Journal: Anesteziol Reanimatol; 1991; (1):25-6. PubMed ID: 1862957.
    Abstract:
    The effect of anesthesia with ketamine (80 mg/kg, intraperitoneally) combined with phenazepam (0.5 mg/kg, subcutaneously) on the reproduction of an elaborated active avoidance reflex in automated reflexometer has been studied on random bred white rats. In has been shown that during 3 hours after the animal is taken out of the lateral position the degree of its learning is significantly lowered and does not return to baseline even a day later. Intramuscular administration of a new cholinesterase inhibitor aminostigmine right after the end of anesthesia restores the disrupted reflex in 3 hours. The optimal antistigmine dose is 0.015 mg/kg, which corresponds to a therapeutic human dose.
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