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  • Title: Better assessment of nodal metastases by PET/CT fusion compared to side-by-side PET/CT in oesophageal cancer.
    Author: Schreurs LM, Pultrum BB, Koopmans KP, Verhoef CC, Jager PL, Van Dam GM, Groen H, Van Der Jagt EJ, Plukker JT.
    Journal: Anticancer Res; 2008; 28(3B):1867-73. PubMed ID: 18630473.
    Abstract:
    BACKGROUND: Recently, positron emission tomography/computed tomography (PET/CT) has been introduced in the staging of oesophageal cancer. The impact of PET/CT fusion in comparison with side-by-side PET/CT in these tumours, was analyzed. PATIENTS AND METHODS: In 61 patients, 18-F-fluorodeoxyglucose (FDG)-PET and multidetector (md)-CT were performed within a two week interval. Software-fusion of md-CT and FDG-PET was correlated with side-by-side FDG-PET/CT reading by two independent investigators. The gold standard was the pathological outcome or clinical evidence of progression during the first year of follow-up. RESULTS: In 18 patients (18/61; 30%), nodal staging improved with software-fusion. The number of nodal metastases increased in five patients and decreased in four patients, leading to up-staging in one patient (2%) and down-staging in three patients (5%). In nine cases (15%), certainty and localization of metastases improved. However, the number of distant metastases did not change and software-fusion did not have an influence on resectability. CONCLUSION: PET/CT fusion substantially improves detection and localization of nodal metastases and may have an impact on locoregional treatment options.
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