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  • Title: [Effect of electroacupuncture on mitochondrial membrane potential and apoptosis in the cerebral cortex in rats with focal cerebral ischemia/reperfusion injury].
    Author: Chen XY, Zhang QL, Bai B.
    Journal: Zhen Ci Yan Jiu; 2008 Apr; 33(2):107-10. PubMed ID: 18630586.
    Abstract:
    OBJECTIVE: To investigate the effect of electroacupuncture (EA) on mitochondrial membrane potential and neuronal apoptosis in the cerebral cortex of rats with focal cerebral ischemia/reperfusion (CI/R) injury. METHODS: Thirty-six male SD rats were uniformly randomized into sham operation (sham), CI/R and CI/R + EA groups. CI/R model was established by middle cerebral artery occlusion (MCAO) and reperfusion. EA (2/15 Hz, 1 mA) was applied to "Shuigou" (GV 26) and "Baihui" (GV 20) for 30 min after CI/R. The mitochondrial membrane potential and neuronal apoptosis in the cerebral cortex (fronto-parietal lobes) in each group were detected by flow cytometer (FCM). RESULTS: In comparison with sham group, the mitochondrial membrane potential of CI/R group decreased significantly (P<0.01), while compared with CI/R group, it increased remarkably in CI/R + EA group (P<0.01). The percentage of neuronal apoptosis in CI/R group was significantly higher than that in sham group (P<0.01), and that of CI/R + EA group was significantly lower than that of CI/R group (P<0.01). CONCLUSION: EA can alleviate CI/R injury partially by up-regulating the mitochondrial membrane potential, which may contribute to its effect in reducing cerebral neuronal apoptosis.
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