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  • Title: Venlafaxine dependence in a patient with a history of alcohol and amineptine misuse.
    Author: Quaglio G, Schifano F, Lugoboni F.
    Journal: Addiction; 2008 Sep; 103(9):1572-4. PubMed ID: 18636997.
    Abstract:
    BACKGROUND: Venlafaxine is an inhibitor of neuronal serotonin and noradrenaline re-uptake and a weak inhibitor of dopamine re-uptake. There was no indication of problems of abuse/dependence during the clinical trials. CASE DESCRIPTION: A 53-year-old client with a history of alcohol and amineptine misuse and a long history of recurrent depression, for which he was prescribed venlafaxine tablets. Over time, he increased the dosage to 50 tablets daily (3750 mg). Large venlafaxine dosages produced amphetamine-like effects, due possibly to the related increase in dopamine turnover. Once hospitalized for detoxification, the patient had a symptomatology which was consistent with a serotonergic discontinuation syndrome. CONCLUSIONS: Physicians should be aware that patients with a history of drug and alcohol abuse might develop venlafaxine dependence.
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