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  • Title: Effects of N-terminal fragments of beta-endorphin on feeding in chicks.
    Author: Yanagita K, Shiraishi J, Fujita M, Bungo T.
    Journal: Neurosci Lett; 2008 Sep 12; 442(2):140-2. PubMed ID: 18638524.
    Abstract:
    It is known that N-terminal fragments of beta-endorphin have biological activities, such as an antagonism effect of beta-endorphin (1-31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of beta-endorphin (1-27) (0.4nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. beta-Endorphin (1-17) (2.0nmol) also increased food intake at 30min postinjection. Co-injection of either beta-endorphin (1-27) or (1-17) was effective in reducing full-length beta-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of beta-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks.
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