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  • Title: Prostaglandin F(2alpha) negatively regulates bone resorption in murine osteoclast development.
    Author: Kamon M, Fujita D, Goto N, Amano H, Sakamoto K.
    Journal: Prostaglandins Other Lipid Mediat; 2008 Dec; 87(1-4):26-33. PubMed ID: 18638564.
    Abstract:
    Prostaglandin (PG) E(2) promotes osteoclastic cell differentiation, but the physiological function of PGF(2alpha) remains unclear. We examined the physiological effects of PGF(2alpha) on osteoclast differentiation using a murine cell line, RAW264, and the column-purified murine bone marrow cells, both of which are differentiable into osteoclast-like multi-nuclear cells. Although PGF(2alpha) did not affect the number of differentiated osteoclasts, PGF(2alpha) reduced the bone resorption activity of osteoclasts developed from both cell types in a pit formation assay. Thus, PGF(2alpha) inhibits bone resorption without affecting the number of osteoclasts, providing a novel molecular mechanism underlying bone metabolism.
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