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  • Title: Improvement of seminal parameters and pregnancy rates after antegrade sclerotherapy of internal spermatic veins.
    Author: Galfano A, Novara G, Iafrate M, De Marco V, Cosentino M, D'Elia C, Artibani W, Ficarra V.
    Journal: Fertil Steril; 2009 Apr; 91(4):1085-9. PubMed ID: 18639874.
    Abstract:
    OBJECTIVE: To evaluate the impact of antegrade scrotal sclerotherapy on seminal parameters and pregnancy rates in varicocele patients who have impairment of seminal parameters and/or couple infertility. DESIGN: Longitudinal, noncomparative study. SETTING: Tertiary university hospital. PATIENT(S): Three hundred sixty-four consecutive varicocele patients with seminal impairment, including 173 (47.5%) patients who were not interested in fertility and 191 (52.5%) who were infertile. INTERVENTION(S): Modified antegrade scrotal sclerotherapy. MAIN OUTCOME MEASURE(S): Increase in sperm count, motility, and/or normal forms in all patients. Pregnancy rates 12 months after treatment in infertile men. RESULT(S): The median patient age was 32 years. Twelve months after treatment, persistent reflux was present in 45 (12.4%) cases. In 188 (51.6%) patients with low sperm number, sperm count statistically significantly improved, from 12 to 19.5 x 10(6) per milliliter. In the 336 (92.3%) patients with asthenospermia, progressive motile forms statistically significantly improved, from 25% to 45%. In the 147 (40.4%) patients with teratospermia, normal forms increased from 17% to 35%. In infertile patients without persistent varicocele, 65 (37.4%) patients fathered offspring. Patients obtaining a pregnancy presented a significantly higher sperm motility than did infertile patients (46% vs. 35%). CONCLUSION(S): Antegrade scrotal sclerotherapy significantly improves sperm count, motility, and morphology. Patients with couple infertility achieved a pregnancy in 37% of cases. Patients achieving pregnancy present a better progressive motility after treatment than patients who did not father any child.
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