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  • Title: Occupational exposure to formaldehyde and biological monitoring of Research Institute workers.
    Author: Pala M, Ugolini D, Ceppi M, Rizzo F, Maiorana L, Bolognesi C, Schilirò T, Gilli G, Bigatti P, Bono R, Vecchio D.
    Journal: Cancer Detect Prev; 2008; 32(2):121-6. PubMed ID: 18639989.
    Abstract:
    AIM: The aim of this study was to verify the presence of a relationship between formaldehyde exposure in the work environment with biological markers of exposure and of effect. METHODS: Exposure to formaldehyde (FA) of 36 workers in different laboratories of a Cancer Research Institute and biomarkers of exposure, such as formaldehyde human serum albumin conjugate (FA-HSA) and biomarkers of effect, such as chromosome aberration (CA), micronuclei (MN) and sister chromatid exchanges (SCEs) were measured in peripheral blood lymphocytes of the same workers. RESULTS: Individual FA levels of exposure ranged from 4.9 microg/m(3) to 268.7 microg/m(3). Subjects with high FA exposure showed a significant increase of the biomarker of exposure FA-HSA, but biomarkers of effect did not show any significant differences. CONCLUSIONS: A significant relationship was observed between occupational exposure to FA and a biological marker of exposure (FA-HSA). The markers of effect used (CA, MN and SCE) failed to indicate the presence of genetic damage.
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