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  • Title: Further study on anti-inflammatory oxygenated steroids from the octocoral Dendronephthya griffini.
    Author: Chao CH, Wen ZH, Su JH, Chen IM, Huang HC, Dai CF, Sheu JH.
    Journal: Steroids; 2008 Dec 22; 73(14):1353-8. PubMed ID: 18640138.
    Abstract:
    Five new steroids, namely griffinisterones F-I (1-4) and griffinipregnone (5) have been isolated from the octocoral Dendronephthya griffini. The structures of these compounds were elucidated by extensive spectroscopic analysis. Compounds 1-3 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the LPS-stimulated RAW264.7 macrophage cells at 10 microM. At the same concentrations 2 also could significantly inhibit the accumulation of the pro-inflammatory COX-2 protein.
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