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  • Title: The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis.
    Author: Paige C, Reid SD, Hanna PC, Claiborne A.
    Journal: J Bacteriol; 2008 Sep; 190(18):6271-5. PubMed ID: 18641144.
    Abstract:
    In Bacillus anthracis, the novel type III pantothenate kinase (PanK(Ba); encoded by coaX) catalyzes the first committed step in coenzyme A biosynthesis. We have demonstrated by analyzing the growth characteristics of a conditional coaX mutant that PanK(Ba) is an essential enzyme, thus contributing to its validation as a new antimicrobial target.
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