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  • Title: Synthesis of a novel class of some 1,3,4-oxadiazole derivatives as antimicrobial agents.
    Author: Chikhalia KH, Vashi DB, Patel MJ.
    Journal: J Enzyme Inhib Med Chem; 2009 Jun; 24(3):617-22. PubMed ID: 18642158.
    Abstract:
    In an effort to discover new candidates with improved antimicrobial activities we report here the synthesis and in vitro biological evaluation of various series of 2-{(3,4,5-trimethoxy phenyl-1,3,4-oxadiazolyl)-5-thio}-4-(morpholino)-6-(phenyl ureido)-s-triazine (7a-i) and 2-{(3,4,5-trimethoxy phenyl-1,3,4-oxadiazolyl)-5-thio}-4-(morpholino)-6-(phenyl thioureido)-s-triazine (8a-g). Antimicrobial properties of the title compounds were investigated against two Gram (+ ve) bacteria (S. aureus, B. subtilis), two Gram (- ve) bacteria (P. aeruginosa, E. coli) and yeast-like fungi (C. albicans) using the broth microdilution method.
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