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  • Title: Effect of IgG immunoadsorption on serum cytokines in MG and LEMS patients.
    Author: Baggi F, Ubiali F, Nava S, Nessi V, Andreetta F, Rigamonti A, Maggi L, Mantegazza R, Antozzi C.
    Journal: J Neuroimmunol; 2008 Sep 15; 201-202():104-10. PubMed ID: 18644634.
    Abstract:
    We investigated the effect of IgG immunoadsorption (IA) on cytokine network in patients with treatment-resistant Myasthenia Gravis (MG) and Lambert-Eaton Syndrome (LEMS). We observed upregulation of interleukin (IL)-10, an anti-inflammatory and B cells growth factor, and reduction of pro-inflammatory factors such as IL-18 and IL-17, in both MG and LEMS after IA. Our observation suggests that the massive removal of antibodies might induce modifications of the cytokine balance linked to T and B cells mediated autoimmunity.
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