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  • Title: Analysis of 900 appendiceal carcinoid tumors for a proposed predictive staging system.
    Author: Landry CS, Woodall C, Scoggins CR, McMasters KM, Martin RC.
    Journal: Arch Surg; 2008 Jul; 143(7):664-70; discussion 670. PubMed ID: 18645109.
    Abstract:
    BACKGROUND: Appendiceal carcinoid tumors (ACTs) are rare, and little is known about the long-term prognosis for these tumors because no staging system exists. Therefore, we sought to investigate prognostic factors associated with ACTs and to create a predictive staging system to accurately estimate prognosis. HYPOTHESIS: In patients with ACTs, TNM staging will accurately predict prognosis. DESIGN: Retrospective review of 15 983 patients with carcinoid tumors in the Surveillance Epidemiology and End Results (SEER) database from January 1, 1977, to December 31, 2004. SETTING: SEER database study. PARTICIPANTS: Nine hundred patients with ACTs (552 females and 348 males; mean age, 47.1 years [age range, 9-89 years]; mean size of the primary tumor, 2.4 cm [range, 0.1-11.5 cm]). Main Outcome Measure Clinicopathologic features in patients with ACTs that affect prognosis using a newly created TNM staging system incorporating these parameters. RESULTS: Lymph node metastasis was found in 137 patients (24%), and distant metastatic disease in 89 patients (10%). Stage-specific survival was statistically significant between stages (P < .001) but not within stages. At multivariate analysis, patient age, primary tumor size, histologic features, lymph node involvement, and distant metastasis were significant factors predicting survival. CONCLUSIONS: Our newly developed TNM staging system accurately predicts prognosis in patients with ACTs. A TNM staging system for ACTs will be helpful not only for physician education about factors that affect the outcome with this disease but also to observe trends in prognosis.
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