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  • Title: Production and characterisation of a monoclonal antibody to progesterone and its effect on fertility.
    Author: Khole V, Hegde U.
    Journal: Indian J Exp Biol; 1991 Jan; 29(1):6-11. PubMed ID: 1864623.
    Abstract:
    A monoclonal antibody reacting with progesterone has been raised by fusion of mouse myeloma cells (SP20) and splenocytes of BALB/c mice hyperimmunized with 4-pregnane 3,20 dione conjugated to bovine serum albumin. Association constant of this antibody for binding with progesterone was 0.22 x 10(9) l/mole. The antibody was highly specific for progesterone. A single ip injection of this antibody brought about an antifertility effect which is influenced by genotype. Antibody treatment brought about a significant decrease in the fetal weight and a slight decrease in the plasma progesterone levels. The antifertility effect could be reversed only up to day 3 by exogenous administration of progesterone.
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