These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [mRNA expression level of nucleostemin in esophageal squamous cell carcinoma tissue].
    Author: Zhang GY, Chen PP, Li SL, Yin L, Gao DL, Le XP, Chen KS, Zhang YH, Zhang QX.
    Journal: Zhonghua Yi Xue Za Zhi; 2008 Mar 04; 88(9):602-5. PubMed ID: 18646714.
    Abstract:
    OBJECTIVE: To investigate the mRNA expression levels of nucleostemin (NS) in human esophageal squamous cell carcinoma tissue. METHODS: Real-time PCR was used to quantify the mRNA expression of NS in the samples of esophageal squamous cell carcinoma tissue and their matched normal esophageal mucosa tissue from 62 patients, 36 males and 26 females, aged (61 +/- 10) (38-75). The relationship between NS mRNA expression level and clinical pathological features was analyzed. RESULTS: The NS mRNA expression level of the 62 cases of esophageal squamous cell carcinoma tissue was(4.5 +/- 2.1), significantly higher than that of the matched normal esophageal mucosa tissue [(2.1 +/- 1.3), t = -5.045, P = 0.000]. The mRNA expression level of NS was associated with tumor grade, depth of infiltration, and lymph node metastasis (all P < 0.05), but not with gender, age, and pathological type (all P > 0.05). Multiple linear regression analysis revealed that clinical and pathological features influenced the NS mRNA expression level (P = 0. 000), and the depth of infiltration and lymph node metastasis were important influencing factors for NS mRNA expression level(both P < 0.05). CONCLUSION: NS may play an important role in the progression and proliferation of esophageal squamous cell carcinoma.
    [Abstract] [Full Text] [Related] [New Search]