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  • Title: [Expression of human leukocyte antigen-DR in idiopathic pulmonary fibrosis].
    Author: Ni LF, Na J, Deng R, Wu R, Liu XM.
    Journal: Zhonghua Yi Xue Za Zhi; 2008 Mar 04; 88(9):622-4. PubMed ID: 18646719.
    Abstract:
    OBJECTIVE: To study the expression of human leukocyte antigen (HLA)-DR in the lungs of the patients with idiopathic pulmonary fibrosis (IPF), and to explore the possible autoimmunity mechanisms of lung fibrosis. METHODS: Methods Immunohistochemistry (SP method) was used to detect the expression of HLA-DR in the lung specimens from 10 IPF patients and in 5 specimens of normal lung tissue immediately adjacent to lung carcinomas as controls. RESULTS: HLA-DR antigens were expressed in the hyperplastic bronchi-alveolar epithelial cells in IPF, but not in the epithelial cells of the normal control lung tissues. The accumulated positive scores of HLA-DR of the IPF group was 27, significantly higher than that of the control group (2, Z = - 3.002, P = 0.001). CONCLUSIONS: Inappropriate HLA-DR expression is present in the bronchi -alveolar epithelium in IPF. Immune dysfunction may play an important role in the development of IPF.
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