These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Complementary strategies to elucidate T helper cell epitopes in myasthenia gravis.
    Author: Jung C, Stoeckle C, Wiesmüller KH, Laub R, Emmrich F, Jung G, Melms A.
    Journal: J Neuroimmunol; 2008 Sep 15; 201-202():41-9. PubMed ID: 18649950.
    Abstract:
    CD4(+) T cells specific for the acetylcholine receptor (AChR) are assumed to play an important role in pathogenesis of myasthenia gravis (MG). A large and diverse number of potential T cell epitopes have been reported for different experimental setups aiming at the identification of disease-relevant T cells in MG. Investigating the T cell response to the epsilon subunit of human AChR, we explore complementary in vitro and in vivo approaches (PBMC from MG patients and mice transgenic for HLA-DR3 and human CD4) to address the possibilities and limitations of different strategies for elucidating natural autoimmune T cell epitopes.
    [Abstract] [Full Text] [Related] [New Search]