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  • Title: Sesquiterpenoids from Hedyosmum orientale.
    Author: Su ZS, Yin S, Zhou ZW, Wu Y, Ding J, Yue JM.
    Journal: J Nat Prod; 2008 Aug; 71(8):1410-3. PubMed ID: 18651771.
    Abstract:
    Five new guaiane-type sesquiterpenoids, hedyosumins A-E (1-5), together with five known ones (6-10), were isolated from the aerial parts of Hedyosmum orientale. Two known sesquiterpenoids, 10alpha-hydroxy-1,5alpha H-guaia-3,7(11)-dien-8alpha,12-olide and 9alpha-hydroxyasterolide, were obtained as natural products for the first time. Their structures were elucidated on the basis of spectroscopic methods. 9alpha-Hydroxyasterolide (7) showed moderate activities against A-549 and HL-60 tumor cell lines with the IC 50 values of 3.1 and 8.8 microM, respectively.
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