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  • Title: Structure-based virtual screening for identification of novel 11beta-HSD1 inhibitors.
    Author: Yang H, Shen Y, Chen J, Jiang Q, Leng Y, Shen J.
    Journal: Eur J Med Chem; 2009 Mar; 44(3):1167-71. PubMed ID: 18653260.
    Abstract:
    Structure-based pharmacophore models were built by using LigandScout and used for virtual screening of the SPECS database to identify new potential 11beta-HSD1 inhibitors. As a refinement of the results obtained from virtual 3D pharmacophore screening, the best fitting virtual hits were subjected to docking study. The resulting compounds were tested in an enzyme assay and revealed several compounds with novel scaffolds that show sub-micromolar activity and high selectivity for 11beta-HSD1 against 11beta-HSD2.
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