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  • Title: Epidural adhesiolysis complicated by cefazolin-induced status epilepticus: two cases.
    Author: Choi JY, Seok HY, Lee SH, Kim BJ, Park KW, Jung KY.
    Journal: Clin Neurol Neurosurg; 2008 Dec; 110(10):1041-3. PubMed ID: 18653274.
    Abstract:
    Cefazolin is a strong epileptogenic agent. We describe two patients presenting with status epilepticus, apparently caused by intrathecal leakage of cefazolin via incidental dural puncture during spinal epidural adhesiolysis. Our cases suggest that the local use of antibiotics, particularly cefazolin, in the form of a mixture with contrast medium during a spinal procedure is not advisable, because of the possible incidental intrathecal leakage and the high convulsive potential of the antibiotics.
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