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  • Title: Acute interstitial nephritis due to deferasirox: a case report.
    Author: Brosnahan G, Gokden N, Swaminathan S.
    Journal: Nephrol Dial Transplant; 2008 Oct; 23(10):3356-8. PubMed ID: 18653899.
    Abstract:
    Deferasirox is a new oral iron chelator used to treat transfusional iron overload. Pre-marketing clinical trials revealed little organ-specific toxicity. Increases in serum creatinine were noted in one-third of patients but were mild and non-progressive. We describe a 62-year-old man with myelodysplastic syndrome who developed a progressive decline in renal function after starting deferasirox. A kidney biopsy showed acute interstitial nephritis with increased eosinophils, suggesting drug hypersensitivity. Deferasirox was discontinued and renal function returned to baseline. This is the first pathological description of deferasirox-related acute kidney injury in humans, which differs from tubular vacuolization observed in animals.
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