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  • Title: A synthetic method for peptide-PEG-lipid conjugates: application of octreotide-PEG-DSPE synthesis.
    Author: Su JC, Tseng CL, Chang TG, Yu WJ, Wu SK.
    Journal: Bioorg Med Chem Lett; 2008 Aug 15; 18(16):4593-6. PubMed ID: 18656351.
    Abstract:
    A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG(2000)-DSPE (OPD(2000)) was used as an example to demonstrate the synthetic approach. The OPD(2000) obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies.
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