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  • Title: The safety of multi-dose vials in allergy immunotherapy.
    Author: Lin SY, Lay PC, Hughes LF, Bass R.
    Journal: Otolaryngol Head Neck Surg; 2008 Aug; 139(2):195-7. PubMed ID: 18656714.
    Abstract:
    OBJECTIVE: To prospectively evaluate the risks of vial contamination after routine clinical use of multiple-dose vials for immunotherapy. STUDY DESIGN: Prospective observational study of immunotherapy vial cultures from June 2007 to January 2008. SETTING: Tertiary care outpatient otolaryngology clinic. RESULTS: Over an 8-month period, 136 consecutive vials were cultured for aerobic and anaerobic bacteria at the 3-month expiration date after regular use in an outpatient allergy clinic and dispensation of multiple doses of injection immunotherapy from each vial. All vials had negative cultures. CONCLUSION: Immunotherapy vials are at low risk to undergo contamination in routine use. Important factors include aseptic technique, bacteriostatic agents, and expiration dating.
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