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  • Title: Radiologic and histologic characterization of silk fibroin as scaffold coating for rabbit tracheal defect repair.
    Author: Ni Y, Zhao X, Zhou L, Shao Z, Yan W, Chen X, Cao Z, Xue Z, Jiang JJ.
    Journal: Otolaryngol Head Neck Surg; 2008 Aug; 139(2):256-61. PubMed ID: 18656725.
    Abstract:
    OBJECTIVES: To explore the feasibility of silk fibroin as a biomaterial coating used in tracheal defect reconstruction. METHODS: Silk fibroin was subcutaneously embedded in three rabbits and as an artificial implant material coating to reconstruct 12 rabbits' tracheal defects. The postoperative radiologic and histologic characterization was summarized. RESULTS: The thickness of the fibroblasts layer covering the porus and nonporus silk fibroin film was 240.4 +/- 9.9 and 302.3 +/- 10.5 microm, respectively, and there was no statistical difference (P > 0.05) within each group. There was no foreign-body granuloma or macrophagocyte infiltration around the silk film. The tracheal reconstruction study showed a normal mucous membrane with normal cilial growth on the artificial implant and no visible granulation tissue in the reconstructed tracheal cavity. CONCLUSIONS: Silk fibroin is a potential new biomaterial coating for tracheal defect reconstruction. The mechanism of silk fibroin appears to promote tracheal mucous membrane, which may be related to its molecular structure and biology.
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