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  • Title: Multidetector-row computed tomography angiography in abdominal aortic aneurysm treated with endovascular repair: evaluation of optimal timing of delayed phase imaging for the detection of low-flow endoleaks.
    Author: Iezzi R, Cotroneo AR, Filippone A, Santoro M, Basilico R, Storto ML.
    Journal: J Comput Assist Tomogr; 2008; 32(4):609-15. PubMed ID: 18664850.
    Abstract:
    PURPOSE: To evaluate the optimal timing of delayed phase imaging for detecting low-flow endoleaks. MATERIALS AND METHODS: Fifty-eight patients with unruptured abdominal aortic aneurysm treated with endovascular repair underwent 1- and 6-month follow-up multidetector row computed tomography (CT) performed during unenhanced, arterial, and delayed phase. At 6-month follow-up, delayed phase imaging, focused on stent graft, was performed with a delay of 60 (early delayed enhanced phase) and 300 seconds (late delayed enhanced phase) after intravenous injection of 120 mL of iodinated nonionic contrast medium (iomeprol 300 mgI/mL, Iomeron), at a flow rate of 3 mL/s via an antecubital vein, with a detector-row configuration of 4 x 1-mm, a 1.25-mm slice width, and a pitch of 6. Six-month follow-up CT images were independently evaluated by 2 readers during 2 different reading sessions: sets A (unenhanced, arterial, and early delayed phase images) and B (unenhanced, arterial, and late delayed phase images). Sensitivity and diagnostic accuracy of both reading sessions were compared. The standard of reference was represented by the combined evaluation of 1- and 6-month CT scans. RESULTS: At standard of reference, 24 of 58 patients had an endoleak classified as type 1 in 2 cases, type 2 in 21 cases, and type 3 in the last 1 case. Seven of 21 type 2 endoleaks were classified as low-flow endoleaks. Set A reading session, including early delayed enhanced phase, allowed the detection of 19 of 24 endoleaks (5 false-negative cases represented by low-flow endoleaks), whereas all endoleaks were detected during set B reading session, including late delayed enhanced phase. Differences between sets A and B in terms of sensitivity and diagnostic accuracy were statistically significant (P < 0.05). CONCLUSIONS: For optimal multidetector CT detection of low-flow endoleaks in patients who underwent endovascular repair, delayed phase should be acquired 300 seconds after injection of contrast medium.
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