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  • Title: Chip-based scanometric detection of mercuric ion using DNA-functionalized gold nanoparticles.
    Author: Lee JS, Mirkin CA.
    Journal: Anal Chem; 2008 Sep 01; 80(17):6805-8. PubMed ID: 18665608.
    Abstract:
    We have developed a chip-based scanometric method for the detection of mercuric ion (Hg (2+)). This method takes advantage of the cooperative binding and catalytic properties of DNA-functionalized gold nanoparticles and the selective binding of a thymine-thymine mismatch for Hg (2+). The limit of detection of this assay in buffer and environmentally relevant samples (lake water) is 10 nM (2 ppb) Hg (2+), which is the U.S. Environmental Protection Agency (EPA) limit of [Hg (2+)] for drinkable water and 1 order of magnitude lower than previous colorimetric assays. This assay is capable of discriminating Hg (2+) from 15 other environmentally relevant metal ions. The method is attractive for potential point-of-use applications due to its high throughput, convenient readout, and portability.
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