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  • Title: Cost-effectiveness of rituximab in refractory cold agglutinin disease.
    Author: Panwar U, Mathews C, Cullis JO.
    Journal: Int J Lab Hematol; 2008 Aug; 30(4):331-3. PubMed ID: 18665831.
    Abstract:
    Cold haemagglutinin disease (CHAD) is an uncommon condition frequently associated with B-cell lymphoproliferative disorders and is refractory to conventional treatments used in autoimmune haemolytic anaemia. Rituximab has been used in this condition with favourable and lasting responses. Cost has been a major limitation to its use in such indication. We present cost-effectiveness analysis of the use of rituximab in two patients with CHAD. Rituximab successfully controlled haemolysis in both cases of CHAD and was found to be cost-effective through reducing transfusion needs.
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