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Title: Metal-free artificial nucleases based on simple oxime and hydroxylamine scaffolds. Author: Fernandes L, Fischer FL, Ribeiro CW, Silveira GP, Sá MM, Nome F, Terenzi H. Journal: Bioorg Med Chem Lett; 2008 Aug 15; 18(16):4499-502. PubMed ID: 18667311. Abstract: Hydrolysis of DNA is of increasing importance in biotechnology and medicine. In this Letter, we present the DNA-cleavage potential of metal-free hydroxylamines and oximes as new members of nucleic acid cleavage agents.[Abstract] [Full Text] [Related] [New Search]