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  • Title: Pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp.
    Author: Igarashi M, Sawa R, Kinoshita N, Hashizume H, Nakagawa N, Homma Y, Nishimura Y, Akamatsu Y.
    Journal: J Antibiot (Tokyo); 2008 Jun; 61(6):387-93. PubMed ID: 18667787.
    Abstract:
    A novel cyclic peptide antibiotic, pargamicin A was isolated from the culture broth of an actinomycete strain. The producing organism, designated ML1-hF4, was identified as a member of the genus Amycolatopsis. Pargamicin A was identified as a novel cyclic hexapeptide antibiotic containing piperazic acid by various spectroscopic analyses. Pargamicin A showed potent antibacterial activity against Staphylococcus aureus strains including MRSA and Enterococcus faecalis/faecium strains including VRE.
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