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  • Title: Insulinomimetic Zn(II) complexes as evaluated by both glucose-uptake activity and inhibition of free fatty acids release in isolated rat adipocytes.
    Author: Nishide M, Yoshikawa Y, Yoshikawa EU, Matsumoto K, Sakurai H, Kajiwara NM.
    Journal: Chem Pharm Bull (Tokyo); 2008 Aug; 56(8):1181-3. PubMed ID: 18670123.
    Abstract:
    We prepared 4 new Zn(II) complexes with Zn(O4), Zn(N(2)O(2)), and Zn(S2O2) coordination modes and evaluated their insulinomimetic activities in an in vitro study. The insulinomimetic activities of bis(pyrrole-2-carboxylato)zinc (Zn(pc)2), bis(alpha-furonic acidato)zinc (Zn(fa)2), bis(thiophene-2-carboxylato)zinc (Zn(tc)2), and bis(thiophene-2-acetato)zinc (Zn(ta)2) complexes were found to be higher than that of zinc sulfate (ZnSO4). Zn(ta)2 showed the highest insulinomimetic activity among the Zn(II) complexes because of its high lipophilicity.
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