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  • Title: Genetic susceptibility to bladder cancer with an emphasis on gene-gene and gene-environmental interactions.
    Author: Horikawa Y, Gu J, Wu X.
    Journal: Curr Opin Urol; 2008 Sep; 18(5):493-8. PubMed ID: 18670273.
    Abstract:
    PURPOSE OF REVIEW: The present article reviews recent reports on molecular epidemiological studies for exploring susceptibility genes for bladder cancer, with particular focus on gene-gene and gene-environmental interactions. RECENT FINDINGS: Recent large case-control studies and meta-analyses have confirmed that N-acetyl transferase2 slow acetylator and glutathione S-transferase Mu null genotype were modest susceptibility factors for bladder cancer, with probable interactions between N-acetyl transferase2 slow acetylator and smoking. Several interesting studies using a multigenic pathway-based genotyping approach and novel statistical tools showed significant interactions among potential functional single nucleotide polymorphisms in DNA repair pathway genes and smoking and gene-diet interaction; however, the resultant interactions warrant validation. SUMMARY: Previous studies using a candidate gene approach have not only identified a few bladder cancer susceptibility loci but also produced a large number of false positive results. A multigenic pathway-based approach may identify gene-gene and gene-environment interactions and increase predictive power. Several statistical tools have been applied to identify gene-gene and gene-environment interactions, but future efforts should be directed toward integrating results obtained from different statistical tools and validating resultant interactions from different studies.
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