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  • Title: Subcortical vascular lesions predict falls at 12 months in elderly patients discharged from a rehabilitation ward.
    Author: Guerini F, Frisoni GB, Marrè A, Turco R, Bellelli G, Trabucchi M.
    Journal: Arch Phys Med Rehabil; 2008 Aug; 89(8):1522-7. PubMed ID: 18674987.
    Abstract:
    OBJECTIVE: To test whether subcortical vascular lesions are associated with falls in elderly patients with gait disorder discharged from a rehabilitation ward. DESIGN: Secondary 12-month follow-up analysis of an observational survey focusing on the prevalence of subcortical vascular lesions in a population of elderly patients discharged from rehabilitation hospitals. SETTING: A rehabilitation and aged care unit. PARTICIPANTS: Consecutively admitted elderly patients (N=214) with gait disorder. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: On admission, all patients underwent comprehensive geriatric assessment including sociodemographics, cognitive and depressive symptoms, nutritional status, physical health, and functional status. Subcortical vascular lesions were assessed on computed tomography films with a validated rating scale. All patients received a standardized rehabilitative program. Twelve months after discharge, all patients were interviewed by telephone, mainly focusing on the occurrence of falls during the follow-up period. Potential predictors of falls were assessed in univariate and multivariate analyses. RESULTS: Univariate predictors of falls were age, sex, Mini-Mental State Examination, Barthel Index on admission, and subcortical vascular lesions. In multivariate analyses, subcortical vascular lesions were the only significant predictor of risk of falling; patients with moderate and severe subcortical vascular lesions scores had a greater risk of falling (odds ratio [OR]=3.0; 95% confidence interval [CI], 1.3-7.1; P=.012; OR=3.9; 95% CI, 1.6-9.2; P=.002, respectively) than those with no subcortical vascular lesions. CONCLUSIONS: Subcortical vascular lesions are associated with falls at 12 months in elderly patients with gait disorder discharged from a rehabilitative ward. Future research is needed to confirm our results.
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