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  • Title: Biomimetic synthesis of the IDO inhibitors exiguamine A and B.
    Author: Volgraf M, Lumb JP, Brastianos HC, Carr G, Chung MK, Münzel M, Mauk AG, Andersen RJ, Trauner D.
    Journal: Nat Chem Biol; 2008 Sep; 4(9):535-7. PubMed ID: 18677305.
    Abstract:
    Biomimetic synthesis is an attempt to assemble natural products along biosynthetic lines without recourse to the full enzymatic machinery of nature. We exemplify this with a total synthesis of exiguamine A and the newly isolated natural product exiguamine B. The most noteworthy feature of this work is an oxidative endgame drawing from the complex chemistry of catecholamines, which allows for ready access to a new class of nanomolar indoleamine-2,3-dioxygenase inhibitors.
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