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  • Title: Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes.
    Author: Rundell KW, Slee JB.
    Journal: J Allergy Clin Immunol; 2008 Aug; 122(2):238-46; quiz 247-8. PubMed ID: 18678339.
    Abstract:
    The prevalence of exercise-induced bronchoconstriction is reported to be high among recreational and elite athletes, yet diagnosis is often symptom-based. Indirect challenges such as the laboratory exercise challenge provide objective criteria for proper diagnosis and treatment. However, a standardized protocol using appropriate exercise intensity, duration, and dry air inhalation is often not implemented, and thus a false-negative test may result. This article reviews and describes the symptom-based diagnosis, the exercise challenge, and other indirect challenges such as eucapnic voluntary hyperpnea, hypertonic saline inhalation, and inhaled powdered mannitol as methods to diagnose and evaluate exercise-induced bronchoconstriction. Advantages and disadvantages of each diagnostic procedure are presented.
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